Auranofin | Exercise | Cytokines | Antioxidant | Pharmaceutical industries | Generics | COVID-19

Drug repurposing plays an important role in treating  COVID-19. Some of the positive results have been shown in patients. Any guess which drug it is, yes Auranofin is a chemical compound that contains gold particles and scientists are experimenting with gold particles to treat diseases such as HIV, cancer, neurogenerative disorders, and bacterial infections. Auranofin is effective in COVID-19. This drug was approved by the FDA to treat rheumatoid arthritis. Many researchers say that the repurposing of a drug is the best way to treat COVID-19.  SARS-CoV-2 needs host cell proteins to replicate them. Some effective drugs interfere with this replication process. Based on the Cell-line studies,  the viral amount within the cells dropped by 95% after 48 hrs of treatment. There is a reduction of inflammation induced by the coronavirus. Auranofin reduces the expression of cytokines, that draws attention by immune cells at the injection site. This team plans to study the effects of drugs on animal models. During the cytokine storm, the immune response gets out of control. As it kills healthy cells and may lead to organ failure. This drug could inhibit the replication of the novel coronavirus and mitigate the infection by reducing the lung associated damage. Lung damage caused by COVID-19 often leads to severe respiratory distress.

Exercise will protect from COVID-19 complications, Yes based on the research conducted by the University of Virginia, they found out that the risk of acute respiratory distress syndrome can be reduced.  Extracellular superoxide dismutase (EcSOD) is an antioxidant that helps in preventing diseases, mostly EcSOD is secreted in the muscles naturally that binds to vital organs. Their production is increased by cardiovascular exercises. Regular exercise has been medicine for a decade.

Will India become a bio-medical hub after the COVID-19 crisis? the answer is yes many start-up firms have started from ideas to proof of concept. The stock market of pharmaceutical industries has been increased for the past few days. But if the government supports more in their annual budget we will have a good health care system and we can rise in the global economy. Make in India concept will surely help any organization in the future. We can proudly say Indian pharmaceutical companies are dominant in generic drug manufacturing. Around 90% of drugs in the U.S are generic and more than one third are manufactured in India. This will have more impact on the future.